Psilocybin microdosers demonstrate greater observed improvements in mood and mental health at one month relative to non-microdosing controls – PubMed Black Hawk Supplements

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Psilocybin microdosing involves repeated self-administration of mushrooms containing psilocybin at doses small enough to not impact regular functioning. Microdose practices are diverse and include combining psilocybin with substances such as lion’s mane mushrooms (Hericium erinaceus; HE) and niacin (vitamin-B3). Public uptake of microdosing has outpaced evidence, mandating further prospective research. Using a naturalistic, observational design, we followed psilocybin microdosers (n = 953) and…
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Psilocybin microdosers demonstrate greater observed improvements in mood and mental health at one month relative to non-microdosing controls - PubMed

Observational Study

Psilocybin microdosers demonstrate greater observed improvements in mood and mental health at one month relative to non-microdosing controls

Joseph M Rootman et al. Sci Rep. .

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Abstract

Psilocybin microdosing involves repeated self-administration of mushrooms containing psilocybin at doses small enough to not impact regular functioning. Microdose practices are diverse and include combining psilocybin with substances such as lion’s mane mushrooms (Hericium erinaceus; HE) and niacin (vitamin-B3). Public uptake of microdosing has outpaced evidence, mandating further prospective research. Using a naturalistic, observational design, we followed psilocybin microdosers (n = 953) and non-microdosing comparators (n = 180) for approximately 30 days and identified small- to medium-sized improvements in mood and mental health that were generally consistent across gender, age and presence of mental health concerns, as we all as improvements in psychomotor performance that were specific to older adults. Supplementary analyses indicated that combining psilocybin with HE and B3 did not impact changes in mood and mental health. However, among older microdosers combining psilocybin, HE and B3 was associated with psychomotor improvements relative to psilocybin alone and psilocybin and HE. Our findings of mood and mental health improvements associated with psilocybin microdosing add to previous studies of psychedelic microdosing by using a comparator group and by examining the consistency of effects across age, gender, and mental health. Findings regarding the combination of psilocybin, HE and B3 are novel and highlight the need for further research to confirm and elucidate these apparent effects.

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Conflict of interest statement

Joseph Rootman has received research funding from Quantified Citizen Technologies, which is a company that produces software for decentralized mobile research that provided the data collection platform for this study. Maggie Kiraga is an employee of Quantified Citizen. Kalin Harvey is co-founder and CTO of Quantified Citizen, co-founder of the Psychedelic Data Project, co-founder and director of the Ketamine Assisted Therapy Association of Canada, and he is also an Investor in MycoMedica Life Sciences. Pamela Kryskow is a member of the clinical advisory board of Numinus Wellness, which is a company that provides psychedelic psychotherapy services. Pamela Kryskow is compensated for this role with Numinus stock. She is a volunteer consultant for Nectara. She is a co-founder of MycoMedica Life Sciences and on the Scientific & Medical Advisory Board. Paul Stamets is an investor in Quantified Citizen, MycoMedica Life Sciences, PBC and owns Fungi Perfecti, LLC which sells Lion Mane supplements. He is an applicant on pending patents combining psilocybin mushrooms, Lions Mane mushrooms and niacin. Eesmyal Santos-Brault is co-founder and CEO of Quantified Citizen, co-founder of the Psychedelic Data Project and an Investor in MycoMedica Life Sciences. Kim PC Kuypers is a principal investigator on research projects, the present study not included, that are sponsored by Mindmed and Silopharma which are companies that are developing psychedelic medicines, and she is a paid member of the scientific advisory board of Clerkenwell Health. Zach Walsh is in a paid advisory relationship with Numinus Wellness and Entheotech BioMedical regarding the medical development of psychedelics, and is a member of the Advisory Board of the Multidisciplinary Association for Psychedelic Studies (MAPS) Canada and MycoMedica Life Sciences.

Figures

Figure 1
Figure 1

Microdosing and mental health. “Baseline” values reflect the mean participant responses collected 0–7 days from study initiation. “Month-1” values reflect the mean participant responses collected 22–35 days following study initiation.

Figure 2
Figure 2

Microdosing and Finger tap test scores. “Baseline” values reflect the mean participant responses collected 0–7 days from study initiation. “Month-1” values reflect the mean participant responses collected 22–35 days following study initiation. PS refers to participants who microdosed with psilocybin in the absence of Lion’s Mane (HE). PS + HE refers to participants that microdose with psilocybin and HE in the absence of niacin (B3). PS + HE + B3 microdosers refers to participants who microdose psilocybin with both HE and B3. Differences in group condition slopes were the subject of Microdose*Time interaction analyses.

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Psilocybin microdosers demonstrate greater observed improvements in mood and mental health at one month relative to non-microdosing controls – PubMed