Challenges in herbal-induced liver injury identification and prevention – PubMed Black Hawk Supplements

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Herbal and dietary supplements (HDS) are being used worldwide at an increasing rate. Mirroring this trend, HDS-induced liver injury, also known as HDS-induced liver injury (HILI), has increased significantly over the past three decades in the Drug-Induced Liver Injury Network (DILIN), now accounting for 20% of cases of drug-induced liver injury (DILI). There are significant challenges in the identification and prevention of HILI due to varying presentations, ability to make clear diagnosis,…
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Challenges in herbal-induced liver injury identification and prevention - PubMed

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doi: 10.1111/liv.16071. Online ahead of print.

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Challenges in herbal-induced liver injury identification and prevention

Dina Halegoua-DeMarzio et al. Liver Int. .

Abstract

Herbal and dietary supplements (HDS) are being used worldwide at an increasing rate. Mirroring this trend, HDS-induced liver injury, also known as HDS-induced liver injury (HILI), has increased significantly over the past three decades in the Drug-Induced Liver Injury Network (DILIN), now accounting for 20% of cases of drug-induced liver injury (DILI). There are significant challenges in the identification and prevention of HILI due to varying presentations, ability to make clear diagnosis, identification of the responsible ingredient, lack of treatment, and lack of regulatory oversight of HDS products to confirm their ingredients and ensure safety. The major implicated agents include anabolic steroids, green tea extract, garcinia cambogia, kratom, ashwagandha, turmeric and multi-ingredient nutritional supplements. Fortunately, with the formation of major DILI consortiums across the world, the last decade has seen advances in the identification of at-risk genetic phenotypes, the use of chemical analysis on multi-ingredient nutritional supplements, and the publication of data/injury patterns of potentially risky HDS.

Keywords: drug‐induced liver injury; hepatotoxicity; herbal and dietary supplements.

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References

REFERENCES

    1. Fontana RJ, Liou I, Reuben A, et al. AASLD practice guidance on drug, herbal, and dietary supplement‐induced liver injury. Hepatology. 2023;77(3):1036‐1065.
    1. Whitsett M, Marzio DH, Rossi S. SlimQuick™‐associated hepatotoxicity resulting in fulminant liver failure and Orthotopic liver transplantation. ACG Case Rep J. 2014;1(4):220‐222.
    1. Byeon JH, Kil JH, Ahn YC, Son CG. Systematic review of published data on herb induced liver injury. J Ethnopharmacol. 2019;233:190‐196.
    1. Zheng EX, Navarro VJ. Liver injury from herbal, dietary, and weight loss supplements: a review. J Clin Transl Hepatol. 2015;3:93‐98.
    1. Kennedy J. Herb and supplement use in the US adult population. Clin Ther. 2005;27:1847‐1858.

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Challenges in herbal-induced liver injury identification and prevention – PubMed