Effect of an acute session of intermittent exercise on trimethylamine N-oxide (TMAO) production following choline ingestion – PubMed Black Hawk Supplements

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CONCLUSION: This suggests that a single bout of intermittent exercise does not alter gut microbial metabolic behaviour and thus does not provide additional cardioprotective benefits related to blood levels of TMAO.
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Effect of an acute session of intermittent exercise on trimethylamine N-oxide (TMAO) production following choline ingestion - PubMed

Effect of an acute session of intermittent exercise on trimethylamine N-oxide (TMAO) production following choline ingestion

Marilyn L Y Ong et al. Metabolomics. .

Abstract

Introduction: Trimethylamine N-oxide (TMAO) is a gut bacteria-dependent metabolite associated with poor cardiovascular health. Exercise is a known cardioprotective activity but the impact of an acute bout of exercise on TMAO production is unknown.

Objectives/methods: This study assessed choline-derived production of TMAO following a single bout of intermittent exercise in a young, healthy cohort.

Results: Choline supplemented after either exercise or a time-matched resting period demonstrated a similar increase in circulating TMAO across an 8-hour period.

Conclusion: This suggests that a single bout of intermittent exercise does not alter gut microbial metabolic behaviour and thus does not provide additional cardioprotective benefits related to blood levels of TMAO.

Keywords: Biomarker; Cardioprotection; Cardiovascular Risk; Exercise; Gut Microbiome; Nutrition.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1

(A) Acute changes in serum TMAO levels over 8 h following choline supplementation. (B) Acute changes in serum choline levels over 8 h following choline supplementation. (C) Acute changes in serum TMAO: choline over 8 h following choline supplementation. All data are presented as means with error bars showing the standard error. * indicates greater than 0 h within each respective trial (p < 0.001). † indicates greater than 0 h within each respective trial (p ≤ 0.002)

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Effect of an acute session of intermittent exercise on trimethylamine N-oxide (TMAO) production following choline ingestion – PubMed