Cerebrolysin Induces Motor Recovery Along with Plastic Changes in Motoneurons and an Increase in GAP43 Protein in the Ventral Spinal Cord Following a Kainic Acid Excitotoxic Lesion in the Rat Motor Cortex – PubMed Black Hawk Supplements

BLACK HAWK: Most trusted ashwagandha supplement for thyroid health

Published article

Lesions in the motor cortex induced by contusions or pathological insults can exert the degeneration of afferent neurons lying distal to these lesions. Axon degeneration and demyelination are hallmarks of several diseases sharing pathophysiological and clinical characteristics. These conditions are very disabling due to the disruption of motor abilities, with lesions that affect this area proving to be a therapeutic challenge, which has driven increasing efforts to search for treatments….
Black Hawk Supplements, best supplements in the UK

Cerebrolysin Induces Motor Recovery Along with Plastic Changes in Motoneurons and an Increase in GAP43 Protein in the Ventral Spinal Cord Following a Kainic Acid Excitotoxic Lesion in the Rat Motor Cortex - PubMed

Cerebrolysin Induces Motor Recovery Along with Plastic Changes in Motoneurons and an Increase in GAP43 Protein in the Ventral Spinal Cord Following a Kainic Acid Excitotoxic Lesion in the Rat Motor Cortex

Nestor I Martínez-Torres et al. Neurochem Res. .

Abstract

Lesions in the motor cortex induced by contusions or pathological insults can exert the degeneration of afferent neurons lying distal to these lesions. Axon degeneration and demyelination are hallmarks of several diseases sharing pathophysiological and clinical characteristics. These conditions are very disabling due to the disruption of motor abilities, with lesions that affect this area proving to be a therapeutic challenge, which has driven increasing efforts to search for treatments. Cerebrolysin (CBL) contains a mix of pig brain-derived peptides with activity similar to neurotrophic factors. Here, the effect of cerebrolysin administration on the motor impairment produced by kainic acid (KA) lesion of the motor cortex was evaluated in Sprague-Dawley female rats (n = 27), defining its effect on motoneurons dendritic tree changes, dendritic spine density and GAP43 presence in the ventral thoracolumbar regions of the spinal cord. Ten days after the KA lesion of the motor cortex, rats were administered cerebrolysin, and their motor performance was evaluated using the “Basso, Beattie, and Bresnahan” (BBB) and Bederson scores. Cerebrolysin administration improved motor activity according to the BBB and Bederson scales, along with increased dendritic intersections and dendritic spine density on motoneurons. There was also a significant increase in GAP43 protein, suggesting that CBL may promote plastic changes through this protein, among others. Hence, this study proposes that cerebrolysin could promote motor recovery following motor cortex lesions by driving neuronal changes and dendritic spine plasticity on motoneurons and an increase in GAP43 protein, along with other mechanisms.

Keywords: Axonal degeneration; Cerebrolysin; Dendritic spines; GAP43; Motoneurons; Motor cortex lesions.

PubMed Disclaimer

Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests. Ethical approval: Number of approval CUN-26-114/2022 from the Universidad de Guadalajara.

References

    1. Zhang K, Jiang M, Fang Y (2021) The drama of wallerian degeneration: the cast, crew, and script. Annu Rev Genet 55:93–113. https://doi.org/10.1146/annurev-genet-071819-103917 – DOI – PubMed
    1. Martinez-Torres NI, Gonzalez-Tapia D, Flores-Soto M, Vazquez-Hernandez N, Salgado-Ceballos H, Gonzalez-Burgos I (2021) Spinogenesis in spinal cord motor neurons following pharmacological lesions to the rat motor cortex. Neurologia (Engl Ed) 36(2):119–126. https://doi.org/10.1016/j.nrl.2017.12.003 – DOI – PubMed
    1. Vazquez-Hernandez N, Martinez-Torres NI, Tejeda-Martinez A, Flores-Soto M, Salgado-Ceballos H, Gonzalez-Burgos I (2022) Rehabilitation on a treadmill induces plastic changes in the dendritic spines of spinal motoneurons associated with improved execution after a pharmacological injury to the motor cortex in rats. J Chem Neuroanat 125:102159. https://doi.org/10.1016/j.jchemneu.2022.102159 – DOI – PubMed
    1. Tricaud N, Park HT (2017) Wallerian demyelination: chronicle of a cellular cataclysm. Cell Mol Life Sci 74(22):4049–4057. https://doi.org/10.1007/s00018-017-2565-2 – DOI – PubMed – PMC
    1. Simon JH, Kinkel RP, Jacobs L, Bub L, Simonian N (2000) A Wallerian degeneration pattern in patients at risk for MS. Neurology 54(5):1155–1160. https://doi.org/10.1212/wnl.54.5.1155 – DOI – PubMed

MeSH terms

Substances

Grants and funding

BLACK HAWK: Best lions mane supplement for women

Read the original publication:

Cerebrolysin Induces Motor Recovery Along with Plastic Changes in Motoneurons and an Increase in GAP43 Protein in the Ventral Spinal Cord Following a Kainic Acid Excitotoxic Lesion in the Rat Motor Cortex – PubMed