Effect of Social Isolation Due to the COVID-19 Pandemic on Cognitive Dysfunction of Patients With Alzheimer Disease: Subanalysis of Double-blinded Noninferiority Study of Donepezil Patches and Donepezil Tablets – PubMed Black Hawk Supplements
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CONCLUSION: Social isolation affects cognitive function on ADRD and this knowledge should be considered in future.
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Randomized Controlled Trial
. 2024 Oct-Dec;38(4):351-357.
doi: 10.1097/WAD.0000000000000648. Epub 2024 Nov 13.
Affiliations
- PMID: 39588690
- DOI: 10.1097/WAD.0000000000000648
Randomized Controlled Trial
Effect of Social Isolation Due to the COVID-19 Pandemic on Cognitive Dysfunction of Patients With Alzheimer Disease: Subanalysis of Double-blinded Noninferiority Study of Donepezil Patches and Donepezil Tablets
Yu Nakamura et al. Alzheimer Dis Assoc Disord. 2024 Oct-Dec.
Abstract
Background: Previous studies were examined effects of social restriction by COVID-19 pandemic on elderly peoples or compared difference of before/after restrictions on patients with Alzheimer disease-related dementia (ADRD). Here, we assessed the effects of restrictions on the cognitive function of the patients by comparing control group.
Methods: We examined the impact on cognitive function using the Alzheimer Disease Assessment Scale (Japanese version) cognitive subscale (ADAS-JCOG), in patients with mild to moderate ADRD by a post hoc subgroup analysis of double-blinded, noninferiority study of donepezil 27.5 mg patches and donepezil hydrochloride 5 mg tablets (JapicCTI-194582). After demonstrating the noninferiority of both treatments, we used combined data for this analysis.
Results: The analyzed subpopulation of the per-protocol set groups was balanced (n=126 and 135, respectively). Patient demographics were similar between subgroups. The difference of ADAS-JCOG scores [least-squares mean (95%CI)] between the groups was 0.388 (-0.377 to 1.152, not statistically significant).
Conclusion: Social isolation affects cognitive function on ADRD and this knowledge should be considered in future.
Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.
Conflict of interest statement
Y.N. has received consultant fees from Teikoku Seiyaku (the sponsor of this study), Eisai, Ono Pharmaceutical and Otsuka Pharmaceutical; lecture fees from Daiichi Sankyo, EA Pharma, Eisai, Eli Lilly Japan, Janssen Pharmaceutical, Meiji Seika Pharma, Mochida, Nippon Chemiphar, Ono Pharmaceutical, Otsuka Pharmaceutical, Sumitomo Pharma, Takeda Pharmaceutical, Towa Pharmaceutical and Viatris; contract research funding or clinical trials from Biogen Japan, MSD and Nippon Boehringer Ingelheim; grants from Daiichi Sankyo, Eisai, Novartis Pharma and Ono Pharmaceutical. T.O., K.N., H.A., and N.N. are employees of Teikoku Seiyaku. The remaining authors declare no conflicts of interest.
References
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