Age and Gender Disparities in the Association of Long-Term Dietary Choline and Choline Compound Intakes with Incident Cognitive Decline in Middle-Aged and Older Chinese Adults: A Prospective Cohort Study – PubMed Black Hawk Supplements
BLACK HAWK: Most trusted lions mane supplement for
Published article
Background/Objectives: The neuroprotective role of dietary choline during adulthood has not yet been conclusively proven. This study aims to investigate the influence of long-term choline and its constituent intakes on cognitive decline in the Chinese population. Methods: A total of 4502 subjects (≥55 years) with at least two waves of completed data and without cognitive decline at baseline were selected from the China Health and Nutrition Survey 1997-2018. Three consecutive 24 h dietary recalls…
Black Hawk Supplements, best supplements in the UK
. 2024 Nov 28;16(23):4121.
doi: 10.3390/nu16234121.
Xiaofang Jia 1 2 , Chang Su 1 2 , Jiguo Zhang 1 2 , Feifei Huang 1 2 , Jing Bai 1 2 , Fangxu Guan 1 2 , Yanli Wei 1 2 , Li Li 1 2 , Yibing Liu 1 , Jingang Ji 1 , Wenwen Du 1 2 , Yifei Ouyang 1 2 , Xiaofan Zhang 1 2 , Bing Zhang 1 2 , Huijun Wang 1 2
Affiliations
- PMID: 39683516
- PMCID: PMC11644459
- DOI: 10.3390/nu16234121
Age and Gender Disparities in the Association of Long-Term Dietary Choline and Choline Compound Intakes with Incident Cognitive Decline in Middle-Aged and Older Chinese Adults: A Prospective Cohort Study
Xiaofang Jia et al. Nutrients. .
Abstract
Background/Objectives: The neuroprotective role of dietary choline during adulthood has not yet been conclusively proven. This study aims to investigate the influence of long-term choline and its constituent intakes on cognitive decline in the Chinese population. Methods: A total of 4502 subjects (≥55 years) with at least two waves of completed data and without cognitive decline at baseline were selected from the China Health and Nutrition Survey 1997-2018. Three consecutive 24 h dietary recalls were performed to collect dietary intake information for choline, phosphatidylcholine (PC), and glycerophosphocholine (GPC) measures. Several items from the Telephone Interview for Cognitive Status (Modified) were employed to perform a cognitive assessment. Cox frailty models were used to estimate hazard ratios (HRs) and 95% CIs. Results: A total of 783 participants developed cognitive decline during 26,080 person-years of follow-up. Cumulative average intakes of choline, PC, and GPC were 188.0, 126.7, and 17.1 mg/d, respectively. In the total population, after full adjustment, subjects in the lower (Q2), medium (Q3), higher (Q4), and highest (Q5) quintiles of dietary choline showed 27.8% (95% CI: 0.584, 0.894), 33.9% (95% CI: 0.522, 0.836), 23.0% (95% CI: 0.599, 0.990), and 29.3% (95% CI: 0.526, 0.949) decreases in the risk of cognitive decline compared to the lowest (Q1), respectively. Similar results were observed in PC but not GPC measures. Both higher choline and PC intakes induced a lower risk of cognitive decline for subjects ≥ 65 years at baseline (Q3 and Q4) and females (Q2-Q5). A marginally significant association of GPC was found for subjects ≥ 65 years (Q5) and males (Q4). Conclusions: These findings identify age and gender disparities relating to the protective associations of dietary choline, PC, and GPC with incident cognitive decline in middle-aged and older Chinese populations.
Keywords: choline; cognitive decline; cohort study; glycerophosphocholine; phosphatidylcholine.
Conflict of interest statement
The authors declare no conflicts of interest.
Figures
Association of dietary choline with incident cognitive decline in total subjects and grouped by baseline age and gender. The Cox frailty model was employed and results are shown as HR (95% CI). Model 1 adjusted for age, gender, education, household income, residence region and urbanization level. Model 2 additionally adjusted for alcohol intake, total physical activity and energy intake. Model 3 additionally adjusted CVD history, BMI, baseline global cognitive score. For gender-stratified analysis, gender was excluded in Model 1. * p < 0.05, ** p < 0.01, *** p < 0.001.
Association of dietary PC with incident cognitive decline in total subjects and grouped by baseline age and gender. The Cox frailty model was employed, and results are shown as HR (95% CI). Model 1 adjusted for age, gender, education, household income, residence region and urbanization level. Model 2 additionally adjusted for alcohol intake, total physical activity, energy intake and choline intake. Model 3 additionally adjusted CVD history, BMI, baseline global cognitive score. For gender-stratified analysis, gender was excluded in Model 1. * p < 0.05, ** p < 0.01, *** p < 0.001.
Association of dietary GPC with incident cognitive decline in total subjects and grouped by baseline age and gender. The Cox frailty model was employed, and results are shown as HR (95% CI). Model 1 adjusted for age, gender, education, household income, residence region and urbanization level. Model 2 additionally adjusted for alcohol intake, total physical activity, energy intake and choline intake. Model 3 additionally adjusted CVD history, BMI, and baseline global cognitive score. For gender-stratified analysis, gender was excluded in Model 1. * p < 0.05, ** p < 0.01.
References
-
- Bai W., Chen P., Cai H., Zhang Q., Su Z., Cheung T., Jackson T., Sha S., Xiang Y.T. Worldwide prevalence of mild cognitive impairment among community dwellers aged 50 years and older: A meta-analysis and systematic review of epidemiology studies. Age Ageing. 2022;51:afac173. doi: 10.1093/ageing/afac173. – DOI – PubMed
MeSH terms
Substances
Grants and funding
BLACK HAWK: Best shilajit supplement for teens
Read the original publication: