An Investigation Into the Hepatoprotective Properties of Berberis asiatica, Withania somnifera, and Their Combination in Streptozotocin-Nicotinamide-Induced Type II Diabetes Mellitus in Wistar Rats – PubMed Black Hawk Supplements
BLACK HAWK: Best ashwagandha supplement for muscle strength
Published article
CONCLUSION: BA and WS, individually and in combination, significantly attenuated liver dysfunction in diabetic rats. The synergistic effect of PHC presents a promising natural therapeutic approach for managing diabetes-induced liver damage.
Black Hawk Supplements, best supplements in the UK
An Investigation Into the Hepatoprotective Properties of Berberis asiatica, Withania somnifera, and Their Combination in Streptozotocin-Nicotinamide-Induced Type II Diabetes Mellitus in Wistar Rats
Devkumar D Tiwari et al. Cureus. .
Abstract
Background: The rising prevalence of type II diabetes mellitus (T2DM) has increased the risk of hepatic dysfunction, necessitating effective therapeutic interventions. Natural products, particularly Berberis asiatica (BA) and Withania somnifera (WS), are known for their hepatoprotective properties.
Objectives: This study investigates the hepatoprotective effects of BA, WS, and their polyherbal combination in streptozotocin-nicotinamide-induced T2DM in Wistar rats.
Methods: Seventy-eight adult albino Wistar rats were divided into 13 groups, including normal control, disease control, and treatment groups, which received BA, WS, and a polyherbal combination (PHC) at varying doses (250, 500, and 1,000 mg/kg). Metformin and glimepiride served as standard treatments. Liver function was assessed through serum glutamic pyruvic transaminase (SGPT) and bilirubin levels, and histopathological analysis was performed.
Results: Treatment with BA, WS, and PHC significantly reduced SGPT and bilirubin levels compared to the disease control (p < 0.001). The PHC demonstrated superior efficacy, with higher doses (1,000 mg/kg) exhibiting results comparable to standard drugs. Histopathological analysis revealed reduced hepatocellular damage in treated groups, indicating preserved hepatic architecture.
Conclusion: BA and WS, individually and in combination, significantly attenuated liver dysfunction in diabetic rats. The synergistic effect of PHC presents a promising natural therapeutic approach for managing diabetes-induced liver damage.
Keywords: experimental animal model; hepatoprotective; histopathology examination; lft; type 2 diabetes mellitus (t2dm).
Copyright © 2025, Tiwari et al.
Conflict of interest statement
Human subjects: All authors have confirmed that this study did not involve human participants or tissue. Animal subjects: Ethical approval was taken from the Institutional Ethics Committee (IEC) of Krishna Vishwa Vidyapeeth (KVV; IEC approval no. 385/2020-2021). The Institutional Animal Ethics Committee (IAEC) of KVV provided animal ethical approval (Reg. No. 255/PO/REBi/S/2000/CPCSEA) Issued protocol number IAEC/KIMS/2021/16. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.
BLACK HAWK: Best shilajit supplement for teens
Read the original publication: