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This clinical review presents what is known about the antiviral features of humic substances (HS) to the benefit of the clinical healthcare provider using available data in humeomics, the study of the soil humeome. It provides the reader with a working framework of historical studies and includes clinically relevant data with the goal of providing a broad appreciation of the antiviral potential of humic substances while also preparing for a translational leap into the clinical application of…
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Clinical review of humic acid as an antiviral: Leadup to translational applications in clinical humeomics - PubMed

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Clinical review of humic acid as an antiviral: Leadup to translational applications in clinical humeomics

David C Socol. Front Pharmacol. .

Abstract

This clinical review presents what is known about the antiviral features of humic substances (HS) to the benefit of the clinical healthcare provider using available data in humeomics, the study of the soil humeome. It provides the reader with a working framework of historical studies and includes clinically relevant data with the goal of providing a broad appreciation of the antiviral potential of humic substances while also preparing for a translational leap into the clinical application of humic acid.

Keywords: Humic acid (HA); antiviral; carboxylated polyanions; extracellular and intracellular mechanisms of action; fulvic acid; humic substances; shilajit.

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Conflict of interest statement

DS is the CEO of Advanced Humeomics (R) and does have an ownership interest.

Figures

FIGURE 1
FIGURE 1

Essential building blocks of humic acid. Created with

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FIGURE 2
FIGURE 2

Binding mechanism of humic acid with spike proteins. Created with

Biorender.com

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FIGURE 3
FIGURE 3

Humic acid binds to viral spike protein receptor binding domains (RBD) and inhibits viral fusion with target cell membrane receptors. The hydrophilic properties of the humic acid molecule attract water to form a hydrogel which encapsulates spike protein RBD and suspends the viral lifecycle. In the presence of fulvic acid, humic acid’s potential to bind spike protein RBDs is impaired, which is the molecule’s primary mechanism of action. Created with

Biorender.com

.

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Clinical review of humic acid as an antiviral: Leadup to translational applications in clinical humeomics – PubMed