How Shilajit-Based Nanocarriers Alter Classical Doxorubicin Delivery to Breast Cancer Cells (MCF-7 and ZR-75-1) – PubMed Black Hawk Supplements

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Chemotherapy has been ineffective in cancer treatment, and efficient delivery of chemotherapeutic agents remains a challenge. In this study, we developed a doxorubicin-loaded shilajit-based nanocarrier (SHN-Dox) using a nanoprecipitation method to enhance Dox uptake into breast cancer cells (MCF-7 and ZR-75-1). After confirmation of the physicochemical properties of the nanocarriers, the cytotoxic and pro-apoptotic effects of SHN-Dox and the production of reactive oxygen species (ROS) were…
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How Shilajit-Based Nanocarriers Alter Classical Doxorubicin Delivery to Breast Cancer Cells (MCF-7 and ZR-75-1) - PubMed

. 2024 Mar 27;15(4):449-456.

doi: 10.1021/acsmedchemlett.3c00538. eCollection 2024 Apr 11.

Affiliations

How Shilajit-Based Nanocarriers Alter Classical Doxorubicin Delivery to Breast Cancer Cells (MCF-7 and ZR-75-1)

Zahra Asadi et al. ACS Med Chem Lett. .

Abstract

Chemotherapy has been ineffective in cancer treatment, and efficient delivery of chemotherapeutic agents remains a challenge. In this study, we developed a doxorubicin-loaded shilajit-based nanocarrier (SHN-Dox) using a nanoprecipitation method to enhance Dox uptake into breast cancer cells (MCF-7 and ZR-75-1). After confirmation of the physicochemical properties of the nanocarriers, the cytotoxic and pro-apoptotic effects of SHN-Dox and the production of reactive oxygen species (ROS) were evaluated on breast cancer cells. SHN-Dox showed a spherical shape with a size of 244 nm and a sustainable release profile of Dox. It exhibited high cytotoxicity against MCF-7 and ZR-75-1 cells, effectively inducing DNA fragmentation in these cells. After 24 h of treatment, SHN-Dox increased the apoptosis rate in MCF-7 cells and raised ROS levels. Therefore, SHN-Dox is a promising carrier that might reduce the side effects of Dox on healthy cells and provide a new strategy for clinical cancer treatment.

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Conflict of interest statement

The authors declare no competing financial interest.

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References

    1. Jokar N.; Velikyan I.; Ahmadzadehfar H.; Rekabpour S. J.; Jafari E.; Ting H. H.; et al. Theranostic Approach in Breast Cancer: A Treasured Tailor for Future Oncology. Clin. Nucl. Med. 2021, 46 (8), e410–e420. 10.1097/RLU.0000000000003678. – DOI – PubMed
    1. Hanna K.; Mayden K. Chemotherapy Treatment Considerations in Metastatic Breast Cancer. J. Adv. Pract. Oncol. 2021, 12 (Supp. 2), 6–12. 10.6004/jadpro.2021.12.2.11. – DOI – PMC – PubMed
    1. Harahap Y.; Ardiningsih P.; Corintias Winarti A.; Purwanto D. J. Analysis of the Doxorubicin and Doxorubicinol in the Plasma of Breast Cancer Patients for Monitoring the Toxicity of Doxorubicin. Drug Des. Dev. Ther. 2020, 14, 3469–75. 10.2147/DDDT.S251144. – DOI – PMC – PubMed
    1. Misiak P.; Niemirowicz-Laskowska K.; Misztalewska-Turkowicz I.; Markiewicz K. H.; Wielgat P.; Car H.; et al. Doxorubicin delivery systems with an acetylacetone-based block in cholesterol-terminated copolymers: Diverse activity against estrogen-dependent and estrogen-independent breast cancer cells. Chem. Phys. Lipids 2022, 245, 10519410.1016/j.chemphyslip.2022.105194. – DOI – PubMed
    1. Mitry M. A.; Edwards J. G. Doxorubicin induced heart failure: Phenotype and molecular mechanisms. Int. J. Cardiol. Heart Vasc. 2016, 10, 17–24. 10.1016/j.ijcha.2015.11.004. – DOI – PMC – PubMed

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How Shilajit-Based Nanocarriers Alter Classical Doxorubicin Delivery to Breast Cancer Cells (MCF-7 and ZR-75-1) – PubMed