Hydrogen-Rich Gas Enhanced Sprint-Interval Performance: Metabolomic Insights into Underlying Mechanisms – PubMed Black Hawk Supplements

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(1) Background: The diversity of blood biomarkers used to assess the metabolic mechanisms of hydrogen limits a comprehensive understanding of its effects on improving exercise performance. This study evaluated the impact of hydrogen-rich gas (HRG) on metabolites following sprint-interval exercise using metabolomics approaches, aiming to elucidate its underlying mechanisms of action. (2) Methods: Ten healthy adult males participated in the Wingate Sprint-interval test (SIT) following 60 min of…
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Hydrogen-Rich Gas Enhanced Sprint-Interval Performance: Metabolomic Insights into Underlying Mechanisms - PubMed

Randomized Controlled Trial

. 2024 Jul 19;16(14):2341.

doi: 10.3390/nu16142341.

Affiliations

Randomized Controlled Trial

Hydrogen-Rich Gas Enhanced Sprint-Interval Performance: Metabolomic Insights into Underlying Mechanisms

Gengxin Dong et al. Nutrients. .

Abstract

(1) Background: The diversity of blood biomarkers used to assess the metabolic mechanisms of hydrogen limits a comprehensive understanding of its effects on improving exercise performance. This study evaluated the impact of hydrogen-rich gas (HRG) on metabolites following sprint-interval exercise using metabolomics approaches, aiming to elucidate its underlying mechanisms of action. (2) Methods: Ten healthy adult males participated in the Wingate Sprint-interval test (SIT) following 60 min of HRG or placebo (air) inhalation. Venous blood samples were collected for metabolomic analysis both before and after gas inhalation and subsequent to completing the SIT. (3) Results: Compared with the placebo, HRG inhalation significantly improved mean power, fatigue index, and time to peak for the fourth sprint and significantly reduced the attenuation values of peak power, mean power, and time to peak between the first and fourth. Metabolomic analysis highlighted the significant upregulation of acetylcarnitine, propionyl-L-carnitine, hypoxanthine, and xanthine upon HRG inhalation, with enrichment pathway analysis suggesting that HRG may foster fat mobilization by enhancing coenzyme A synthesis, promoting glycerophospholipid metabolism, and suppressing insulin levels. (4) Conclusions: Inhaling HRG before an SIT enhances end-stage anaerobic sprint capabilities and mitigates fatigue. Metabolomic analysis suggests that HRG may enhance ATP recovery during interval stages by accelerating fat oxidation, providing increased energy replenishment for late-stage sprints.

Keywords: anaerobic exercise; fat oxidation; hydrogen-rich gas; metabolomics; sprint-interval training.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1

Experimental test sequence and procedure. Pre-gas: before gas inhalation; post-gas: immediately after gas inhalation; Post-SIT: immediately after sprint-interval test.

Figure 2
Figure 2

Top 20 differential metabolic pathways for differential metabolites in the hydrogen group. RichFactor represents the ratio of the number of differential metabolites in a metabolic pathway to the total number of metabolites identified in that pathway, a higher value indicates a higher degree of enrichment of differential metabolites within the pathway; the y-axis represents the differential metabolic pathways, such as choline metabolism in cancer, which suggests that hydrogen-rich gas, compared to air, can promote the choline metabolic pathway in cancer; Number, the size of the dot represents the number of differential metabolites in the corresponding pathway, a larger dot indicates a greater number of differential metabolites within that pathway; p-value, represents the p-value from the hypergeometric test, a smaller p-value indicates greater reliability and statistical significance of the test.

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Hydrogen-Rich Gas Enhanced Sprint-Interval Performance: Metabolomic Insights into Underlying Mechanisms – PubMed