Paraxanthine enhances memory and neuroplasticity more than caffeine in rats – PubMed Black Hawk Supplements
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Paraxanthine (PXN) is the main metabolite of caffeine (CAF). PXN supplementation has been shown to increase measures of cognition, memory, reasoning, response time, and sustained attention; however, no preclinical study has compared the effects of PXN with those of CAF. The aim of this study was to compare the effects of PXN and CAF on memory and related biomarkers in rats. The effects of two different doses of PXN (PXN LOW, PXN HIGH), CAF (CAF HIGH), and a control group on cognition (escape…
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Paraxanthine enhances memory and neuroplasticity more than caffeine in rats
Ralf Jäger et al. Exp Brain Res. .
Abstract
Paraxanthine (PXN) is the main metabolite of caffeine (CAF). PXN supplementation has been shown to increase measures of cognition, memory, reasoning, response time, and sustained attention; however, no preclinical study has compared the effects of PXN with those of CAF. The aim of this study was to compare the effects of PXN and CAF on memory and related biomarkers in rats. The effects of two different doses of PXN (PXN LOW, PXN HIGH), CAF (CAF HIGH), and a control group on cognition (escape latency in the Morris water maze test), neurotransmitters (acetylcholine, dopamine, and gamma-aminobutyric acid), and neurochemicals (BDNF, catalase, glutathione, and cyclic GMP) were analyzed from whole brain samples in young (8 weeks old) and aged (16 months old) rats. Compared to the control group, escape latency improved in PXN LOW, PXN HIGH, and CAF HIGH (all P < 0.05) in young animals, and in PXN HIGH and CAF HIGH in older animals (P < 0.001). PXN HIGH improved escape latency compared to CAF HIGH in both young (P < 0.001) and old animals (P = 0.003). BDNF levels increased in PXN LOW, PXN HIGH, and CAF HIGH (all P < 0.001), with PXN HIGH increasing BDNF to a greater extent compared to CAF HIGH (P = 0.03). PXN HIGH also significantly increased BDNF levels compared to PXN LOW (P < 0.001). All other neurotransmitters and neurochemicals significantly increased in the PXN HIGH and CAF HIGH groups compared to the control. In conclusion, PXN showed greater improvements in cognition and BDNF levels compared to CAF, further substantiating PXN as a nootropic with greater benefits compared to CAF.
Keywords: BDNF; Caffeine; Cognition; Learning; Nootropics; Paraxanthine.
© 2024. The Author(s).
Conflict of interest statement
Declarations. Conflict of interest: R.J., M.P., S.D.W. and K.L. are researchers and principals of Ingenious Ingredients, the sponsor of the study, and inventors of numerous patent applications for the use of paraxanthine but have been involved in data collection or analysis. R.J., M.P. and S.D.W. serve on the scientific advisory board and K.L. is the CEO of NNB Nutrition, the manufacturer of the paraxanthine used in this study. S.A. is an employee of Iovate Health Sciences, a distributor of paraxanthine, but has not been involved in data collection or analysis. A.G. is employed by Radiant Research Services Pvt. Ltd., and Radiant Research is a CRO who has received funding from Ingenious Ingredients to conduct this study. G.M.T. provides consulting services, including statistical analysis and dietary supplement formulation, through Tinsley Consulting LLC but has no conflicts of interest related to the use of paraxanthine. M.O. declares no competing interests.
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References
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- Arendash GW, Schleif W, Rezai-Zadeh K, Jackson EK, Zacharia LC, Cracchiolo JR et al (2006) Caffeine protects Alzheimer’s mice against cognitive impairment and reduces brain beta-amyloid production. Neuroscience 142(4):941–952. 10.1016/j.neuroscience.2006.07.021 – PubMed
-
- Barcelos RP, Souza MA, Amaral GP, Stefanello ST, Bresciani G, Fighera MR et al (2014) Caffeine supplementation modulates oxidative stress markers in the liver of trained rats. Life Sci 96(1–2):40–45. 10.1016/j.lfs.2013.12.002 – PubMed
-
- Benowitz NL, Jacob P3, Mayan H, Denaro C (1995) Sympathomimetic effects of paraxanthine and caffeine in humans. Clin Pharmacol Ther 58(6):684–691. 10.1016/0009-9236(95)90025-X – PubMed
-
- Bettio LEB, Rajendran L, Gil-Mohapel J (2017) The effects of aging in the hippocampus and cognitive decline. Neurosci Biobehav Rev 79:66–86. 10.1016/j.neubiorev.2017.04.030 – PubMed
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Paraxanthine enhances memory and neuroplasticity more than caffeine in rats – PubMed