Various investigations of ameliorative role of Ashwagandha seeds (Withania somnifera) against amoxicillin toxicity – PubMed Black Hawk Supplements

BLACK HAWK: Most trusted shilajit supplement for immune system

Published article

Several studies showed the adverse effects of amoxicillin on various body organs. So, this research has been designed to evaluate the modulatory role of Ashwagandha seed extract (ASE) against amoxicillin (AM) toxicity. Rats treated with AM (90 mg/kg), protected by ASE doses (100, 200 and 300 mg/kg), and treated by ASE at the same three doses. At the end of the experimental period, DNA comet assay, cytogenetic examinations, sperm-shape analysis, evaluation of the malondialdehyde (MDA)…
Black Hawk Supplements, best supplements in the UK

Various investigations of ameliorative role of Ashwagandha seeds (Withania somnifera) against amoxicillin toxicity - PubMed

. 2024 Jun 12;13(3):tfae091.

doi: 10.1093/toxres/tfae091. eCollection 2024 Jun.

Affiliations

Various investigations of ameliorative role of Ashwagandha seeds (Withania somnifera) against amoxicillin toxicity

Mohamed M M Elnasharty et al. Toxicol Res (Camb). .

Abstract

Several studies showed the adverse effects of amoxicillin on various body organs. So, this research has been designed to evaluate the modulatory role of Ashwagandha seed extract (ASE) against amoxicillin (AM) toxicity. Rats treated with AM (90 mg/kg), protected by ASE doses (100, 200 and 300 mg/kg), and treated by ASE at the same three doses. At the end of the experimental period, DNA comet assay, cytogenetic examinations, sperm-shape analysis, evaluation of the malondialdehyde (MDA) percentages, histopathological examinations, and biophysical tests (modulus, relaxation time, permittivity, entropy, and internal energy change of brain) were documented. The results confirmed that AM treatment induced significant elevation of DNA damage, cytogenetic aberrations, and MDA content in brain, liver, and testis tissues and sperm-shape anomalies. ASE treatment significantly minimized the genetic changes, sperm-shape anomalies, and MDA generation. These enhancements were more pronounced by protective ASE and increased by increasing the dose level. In histopathological examinations, AM treatment caused neurotoxicity in brain tissue. ASE treatment, partially, minimized these damages and the positive effects of therapeutic ASE were more noticeable. Biophysical parameters showed that therapeutic ASE was better for relaxation time, permittivity, and free energy change. Protective and therapeutic ASE were able to recover entropy and internal energy changes in variant degrees.

Keywords: amoxicillin; biochemistry; biophysics; dielectric parameters; genotoxicity; toxicity.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

References

    1. Atli O, Demir-Ozkay U, Ilgin S, Aydin TH, Akbulut EN, Sener E. Evidence for neurotoxicity associated with amoxicillin in juvenile rats. Hum Exp Toxicol. 2016:35(8):866–876. – PubMed
    1. Karaman M, Budak H, Ciftci M. Amoxicillin and gentamicin antibiotics treatment adversely influence the fertility and morphology through decreasing the Dazl gene expression level and increasing the oxidative stress. Arch Physiol Biochem. 2019:125(5):447–455. – PubMed
    1. El-Kholy WM, Hemieda FAE, Elabani GM. Role of cinnamon extract in the protection against amoxicillin/clavulanate-induced liver damage in rats. J Pharm Biol Sci. 2019:14(1):14–21.
    1. Brunton L, Chabner B, Knollman B. Goodman and Gilman’s. In: The pharmacological basis of therapeutics. 12th ed. Laurence L. Brunton, New York: McGraw-Hill Education; 2011
    1. Katzing BG, Trevor AJ. Basic and clinical pharmacology. 13th ed. New York: McGraw-Hill Education; 2015

BLACK HAWK: Best shilajit supplement for women

Read the original publication:

Various investigations of ameliorative role of Ashwagandha seeds (Withania somnifera) against amoxicillin toxicity – PubMed